S6883, Sigma-Aldrich Substance P acetate salt hydrate, is not to be used in/on humans for any purpose.
S6883
Substance P acetate salt hydrate
≥95% (HPLC), powder
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0.5 MG
₹6,181.08
1 MG
₹10,272.93
5 MG
₹36,263.75
10 MG
₹49,253.75
25 MG
₹1,04,558.68
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0.5 MG
₹6,181.08
1 MG
₹10,272.93
5 MG
₹36,263.75
10 MG
₹49,253.75
25 MG
₹1,04,558.68
About This Item
Empirical Formula (Hill Notation):
C63H98N18O13S · xC2H4O2 · yH2O
CAS Number:
Molecular Weight:
1347.63 (anhydrous free base basis)
Beilstein:
5153552
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
mol wt
1348 Da by calculation (Average Mass)
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
solubility
0.1 M acetic acid: 1 mg/mL
UniProt accession no.
storage temp.
−20°C
SMILES string
[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
InChI
1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
InChI key
VHKFRLDSEZYWAC-CIYRQLMPSA-N
Gene Information
human ... TAC1(6863)
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Amino Acid Sequence
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
General description
Research area: Cell Signaling
Substance P is a member of the tachykinin family of peptides.[1] It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.[2][3]
Substance P is a member of the tachykinin family of peptides.[1] It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.[2][3]
Application
Substance P acetate salt hydrate has been:
- used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice[4]
- administered in central nucleus (ACE) in rat to study its positive reinforcing effects[5]
- used in competition binding assays[6]
- used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat[7]
Biochem/physiol Actions
NK-1 agonist; potent vasodilator and hypotensive agent.
NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.[2]
antibody
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
The role of substance P in inflammatory disease.
O'Connor TM
Journal of Cellular Physiology, 201(2), 167-180 (2004)
Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference
Kertes, E, et al.
Behavioural Brain Research, 215(1), 152-155 (2010)
Wei Wang et al.
American journal of physiology. Heart and circulatory physiology, 297(2), H726-H734 (2009-06-16)
Muscular lymphatics use both phasic and tonic contractions to transport lymph for conducting their vital functions. The molecular mechanisms regulating lymphatic muscle contractions are not well understood. Based on the well-established finding that the phosphorylation of myosin light chain 20
Inhibition of myosin light chain phosphorylation
Zawieja A, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 297(1), H726-H734 (2009)
The effect of capsaicin on substance P expression in pulp tissue inflammation.
Caviedes-Bucheli J
International Endodontic Journal, 38(1), 30-33 (2005)
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Hi, I would like to buy substance P for my research in humans. In particular, I plan to administer 20-minute infusions (8 pmol/kg/min) in volunteers. Can you confirm that your product is suitable?
1 answer-
Helpful?
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How should Substance P acetate salt hydrate, Product S6883, be dissolved?
1 answer-
As mentioned in the 'PROPERTIES' section of the Product Detail Page, this product can be dissolved in
0.1 M acetic acid: 1 mg/mL.Helpful?
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