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COO/COA

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P2495

Phalloidin, Coumarin Labeled

Name: Phalloidin, Coumarin Labeled
Brand: SIGMA

for actin detection

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About This Item

Empirical Formula (Hill Notation):

C₆₂H₇₅N₁₁O₁₅S₂

Molecular Weight:

1278.45

UNSPSC Code:

12352204

PubChem Substance ID:

329820138

form

solid

solubility

methanol: 1 mg/mL, clear, colorless to light yellow-green

storage temp.

−20°C

InChI

1S/C62H75N11O15S2/c1-8-71(9-2)36-18-19-38-30(3)50(61(86)88-46(38)22-36)34-14-16-35(17-15-34)73-49(77)25-47(60(73)85)89-21-20-48(76)63-29-62(7,87)26-43-55(81)64-32(5)53(79)70-51(33(6)74)57(83)68-44-28-90-58-40(39-12-10-11-13-41(39)69-58)24-42(54(80)67-43)66-52(78)31(4)65-56(82)45-23-37(75)27-72(45)59(44)84/h10-19,22,31-33,37,42-45,47,51,69,74-75,87H,8-9,20-21,23-29H2,1-7H3,(H,63,76)(H,64,81)(H,65,82)(H,66,78)(H,67,80)(H,68,83)(H,70,79)/t31-,32-,33-,37-,42-,43-,44-,45-,47?,51+,62+/m0/s1

InChI key

GNSRKMXDGGXWDM-AZPABDIKSA-N

Application

A fluorescent phallotoxin which may be used to identify filamentous actin.

Preparation Note

From phalloidin isolated from Amanita phalloides mushrooms

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Precautionary Statements

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females.

V Padmanabhan et al.

Endocrinology, 151(2), 595-605 (2009-12-08)

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women and is exacerbated by obesity. Exposure of ewes to excess testosterone (T) from d 30-90 of gestation culminates in anovulation, functional hyperandrogenism, LH excess, and polyfollicular ovaries, features

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.

Steve Dos-Santos Carvalho et al.

eLife, 9 (2020-01-08)

Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth and guidance. Whether planar cell polarity (PCP) proteins, which regulate cytoskeleton dynamics and appear necessary for some axon guidance, also mediate interactions with membrane adhesion is

ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.

Shanhui Ren et al.

PLoS pathogens, 16(6), e1008514-e1008514 (2020-06-02)

Deoxyribonucleic acid (DNA) damage response (DDR) is the fundamental cellular response for maintaining genomic integrity and suppressing tumorigenesis. The activation of ataxia telangiectasia-mutated (ATM) kinase is central to DNA double-strand break (DSB) for maintaining host-genome integrity in mammalian cells. Oncolytic

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