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P0053

Sigma-Aldrich

PGLa

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About This Item

Empirical Formula (Hill Notation):
C88H162N26O22S
CAS Number:
Molecular Weight:
1968.45
UNSPSC Code:
51102829
NACRES:
NA.85

form

solid

Quality Level

solubility

H2O: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
fungi
viruses

Mode of action

cell membrane | interferes

storage temp.

2-8°C

InChI

1S/C88H162N26O22S/c1-19-48(9)69(113-78(126)52(13)97-66(117)42-95-72(120)50(11)98-79(127)59(31-23-27-36-91)108-85(133)64(44-115)111-77(125)54(15)100-81(129)61(33-38-137-18)104-65(116)41-93)87(135)101-51(12)73(121)96-43-67(118)105-57(29-21-25-34-89)82(130)114-70(49(10)20-2)88(136)103-55(16)74(122)106-60(32-24-28-37-92)83(131)112-68(47(7)8)86(134)102-56(17)76(124)110-63(40-46(5)6)84(132)107-58(30-22-26-35-90)80(128)99-53(14)75(123)109-62(71(94)119)39-45(3)4/h45-64,68-70,115H,19-44,89-93H2,1-18H3,(H2,94,119)(H,95,120)(H,96,121)(H,97,117)(H,98,127)(H,99,128)(H,100,129)(H,101,135)(H,102,134)(H,103,136)(H,104,116)(H,105,118)(H,106,122)(H,107,132)(H,108,133)(H,109,123)(H,110,124)(H,111,125)(H,112,131)(H,113,126)(H,114,130)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-/m0/s1

InChI key

PJRSUKFWFKUDTH-JWDJOUOUSA-N

Amino Acid Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2

General description

Chemical structure: peptide

Application

PGLa is a cationic antimicrobial peptide (AMP) originally isolated from frog. It has been shown to have antibacterial,1 antifungal,2 and antiviral,3 activities. It is used to study novel peptide fragments that originate from PGLa[1] and multinucleated gastric mucosal cells of Xenopus laevis[2].

Biochem/physiol Actions

The precursors of PGLa are caerulein and xenopsin[1]. The mechanism of action of PGLa against Gram-negative bacteria is disruption of the cellular lipid bilayer.4 It is used to induce transmembrane pore formation in lipid bilayers and bacterial cell membranes. It is used in combination with magainin 2 for a synergistic effect.

Other Notes

500ug
Keep container tightly closed in a dry and well-ventilated place.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Yanfang Yang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 96(1), 139-151 (2010-11-19)
Localized dual-drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly(L-lactide-co-glycolide) (PLGA)/β-tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (BSA) were prepared by incorporating Dex-loaded and BSA-loaded microspheres into the
R S Bose et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 19(2), 271-276 (2012-01-21)
There is no robust consensus on the efficacy of polyglycolic/polylactic acid (PGLA)-coated coils used in the endovascular embolization of intracranial aneurysms. We present a comparative study of bare platinum coils and PGLA-coated Gugliemi Detachable Coils (GDC) in the treatment of
O O Ojo et al.
Biochemical and biophysical research communications, 431(1), 14-18 (2013-01-08)
Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and
Meng Ao et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 93(2), 551-556 (2010-03-13)
To prepare the Gd-DTPA-loaded poly (lactic-co-glycolic acid) (PLGA) microbubbles for both ultrasound imaging and MRI imaging. Biodegradable high-molecular-weight poly (lactic-co-glycolic acid) (PLGA) was used as an encapsulating vehicle to fabricate a contrast agent composed of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA)
K S Moore et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40(3), 367-378 (1992-03-01)
We have characterized a novel peptide-containing cell within the gastric mucosa of Xenopus laevis. The cell is a spherical, multinucleated syncytial structure containing a cytoplasmic space filled with dense rice-shaped granules, and is strikingly similar in morphology to the well-studied

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