Ras association domain family member 5 (RASSF5) is also known as novel Ras effector- 1 (NORE-1). It exists in three isoforms and the gene encoding it is located on human chromosome 1q32.1.
Immunogen
peptide corresponding to the NORE1 protein (amino acids 313-329). This sequence is located in the RA domain of NORE1 and is 100% conserved between human, mouse, rat, and hamster.
Biochem/physiol Actions
Ras association domain family member 5 (RASSF5) is a tumor suppressor protein. It interacts with kinases like mammalian sterile 20-like kinase 1/2 (MST1/2). RASSF5 is involved in the regulation of cell cycle and apoptosis.
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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Ras association (RalGDS/AF-6) domain family member RASSF5 has been implicated in a variety of key biological processes, including cell proliferation, cell cycle regulation and apoptosis. It is believed to play an important role in tumorigenesis as a tumor suppressor in
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NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains. The SARAH domain (residues 366-413) of human NORE1 was expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion
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