Skip to Content
Merck
All Photos(1)

Key Documents

M8631

Sigma-Aldrich

Melanin

Synthetic

Sign Into View Organizational & Contract Pricing

Select a Size

100 MG
₹8,021.33
250 MG
₹14,180.75
1 G
₹39,532.90

₹8,021.33

In StockDetails

Request a Bulk Order
All Photos(1)

Select a Size

Change View
100 MG
₹8,021.33
250 MG
₹14,180.75
1 G
₹39,532.90

About This Item

CAS Number:
8049-97-6
EC Number:
232-473-6
MDL number:
MFCD00131581
UNSPSC Code:
12352204
NACRES:
NA.83

₹8,021.33

In StockDetails

Request a Bulk Order

Quality Level

100

form

powder

storage temp.

−20°C

SMILES string

[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChI key

XUMBMVFBXHLACL-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Melanin is a vital pigment present on the surface structures of vertebrates,[1] which contribute to skin color.[2] It has three forms such as, eumelanin, pheomelanin and neuromelanin.[2] Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome.[1]

Application

Melanin has been used:
  • in spectrophotometry[3]
  • to study its effect on reverse transcription polymerase chain reaction (RT-PCR) inhibition and effect of BSA (bovine serum albumin) in overcoming the inhibition[4]
  • as an absorber for skin layer in near-infrared tissue spectra[5]
  • Raman spectroscopy[6]

Preparation Note

Prepared by oxidation of tyrosine with hydrogen peroxide.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCL8556
BCCK2954
BCCK7608
BCCH4437
BCCF0394

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Fengmei Zou et al.
Biomedical optics express, 1(3), 748-761 (2011-01-25)
An accurate SO(2) prediction method for using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is proposed. The method fitted the NIR spectra to a Taylor expansion attenuation model, and used the simulated annealing method to initialize the nonlinear least
Justyna M Drewnowska et al.
PloS one, 10(4), e0125428-e0125428 (2015-04-25)
Although melanin is known for protecting living organisms from harmful physical and chemical factors, its synthesis is rarely observed among endospore-forming Bacillus cereus sensu lato. Here, for the first time, we reported that psychrotolerant Bacillus weihenstephanensis from Northeastern Poland can
Miguel J Beltrán-García et al.
PloS one, 9(3), e91616-e91616 (2014-03-22)
In pathogenic fungi, melanin contributes to virulence, allowing tissue invasion and inactivation of the plant defence system, but has never been implicated as a factor for host cell death, or as a light-activated phytotoxin. Our research shows that melanin synthesized
Diorders of Pigmentation
Zaidi Z, et al.
Treatment of Skin Diseases, 159-170 (2019)
Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes
Yoshino M, et al.
International Immunology, 18(11), 1541-1548 (2006)
View All Related Papers

Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can this product be dissolved in water?

    1 answer

    1. Product M8631 is not tested for solubility in water. The solubility is tested in 1N NH4OH at 20 mg/ml.

      Helpful?

  4. We have used this melanin product. Is it known whether it is in oxidized form? Any information about the exact chemical structure ?

    1 answer

    1. This synthetic melanin product was prepared by oxidation of tyrosine with hydrogen peroxide.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service