Skip to Content
Merck
All Photos(1)

Documents

M5449

Sigma-Aldrich

MKT-077

≥98% (HPLC), powder

Synonym(s):

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride, FJ-776

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
C21H22N3OS2Cl
CAS Number:
147366-41-4
Molecular Weight:
432.00
MDL number:
MFCD27665468
UNSPSC Code:
12352200
PubChem Substance ID:
329818014
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

orange to red

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]

InChI

1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;

InChI key

VSKYOTRJSLYFHX-UXJRWBAGSA-M

Related Categories

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tuoen Liu et al.
PloS one, 12(2), e0170470-e0170470 (2017-02-09)
Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis
Jemma Day et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 14611-14624 (2019-11-07)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial
Victoria J Gennaro et al.
BMC cancer, 19(1), 258-258 (2019-03-25)
The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate
Sunil Joseph et al.
Biology open, 6(4), 481-488 (2017-03-16)
Earlier studies suggested that
Ahmed Edan Dhamad et al.
American journal of physiology. Cell physiology, 318(2), C289-C303 (2019-12-05)
Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service