IgG subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids.
Immunogen
Mouse IgG, Fc fragment
Application
Anti-Mouse IgG (Fc specific) antibody has been used in:
enzyme linked immunosorbent assay (ELISA)
Ouchterlony double diffusion
anti-drug antibody immunoassay
immunoelectrophoresis
Biochem/physiol Actions
Immunoglobulin G (IgG) is a glycoprotein antibody that regulates immune responses such as phagocytosis and is also involved in the development of autoimmune diseases . Mouse IgGs have four distinct isotypes, namely, IgG1, IgG2a, IgG2b, and IgG3. IgG1 regulates complement fixation in mice
Other Notes
Antibody adsorbed with human IgG and rat serum proteins
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Adsorbed to reduce background with human or rat samples.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Annexin A1 (AnxA1) modulates neutrophil life span and bone marrow/blood cell trafficking thorough activation of formyl-peptide receptors (FPRs). Here, we investigated the effect of exogenous AnxA1 on haematopoiesis in the mouse. Treatment of C57BL/6 mice with recombinant AnxA1 (rAnxA1) reduced
Journal of pharmaceutical sciences, 109(1), 845-853 (2019-10-20)
Silicone oil is a lubricant for prefilled syringes (PFS), a common primary container for biotherapeutics. Silicone oil particles (SiOP) shed from PFS are a concern for patients due to their potential for increased immunogenicity and therefore also of regulatory concern.
Integrating molecular detection and response to create self-signalling antibodies
Randle B, et al.
Biochemical and Biophysical Research Communications, 324(2), 504-510 (2004)
Universal immunoassay applied during early development of large molecules to understand impact of immunogenicity on biotherapeutic exposure
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