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L8533

Sigma-Aldrich

Lansoprazole

≥98% (TLC), powder

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About This Item

Empirical Formula (Hill Notation):
C16H14F3N3O2S
CAS Number:
103577-45-3
Molecular Weight:
369.36
MDL number:
MFCD00866873
UNSPSC Code:
12352200
PubChem Substance ID:
24278520
NACRES:
NA.77

Assay

≥98% (TLC)

form

powder

color

off-white

originator

Novartis

storage temp.

2-8°C

SMILES string

Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F

InChI

1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

InChI key

MJIHNNLFOKEZEW-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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Biochem/physiol Actions

Gastric proton pump inhibitor.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L B Barradell et al.
Drugs, 44(2), 225-250 (1992-08-01)
Lansoprazole is an effective acid pump inhibitor acting at the final enzymatic step of the acid secretory pathway of the parietal cell, decreasing gastric acid secretion regardless of the primary stimulus. Results of short term (less than 8 weeks) clinical
T B Bödvarsdóttir et al.
Diabetologia, 53(10), 2220-2223 (2010-06-30)
Gastrin has been implicated in islet growth/neogenesis, and proton pump inhibitors (PPIs) have been shown to increase endogenous gastrin levels in animals and humans. Therefore, we investigated the effect of PPIs in a model of type 2 diabetes, Psammomys obesus.
Lin Ye et al.
Journal of cellular and molecular medicine, 25(5), 2703-2713 (2021-02-20)
Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse
Sayed M Derayea et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 209, 209-216 (2018-11-07)
Cytochrome P450 (CYP) is a class of heme-containing enzymes which mainly catalyze a monooxygenation reaction of various chemicals, and hence CYP plays a key role in the drug metabolism. Although CYP2C19 isoform is a minor hepatic CYP, it metabolizes clinically
Hiroshi Satoh
Current pharmaceutical design, 19(1), 67-75 (2012-09-07)
The proton pump inhibitors (PPIs) lansoprazole (LPZ) and omeprazole (OPZ) have been widely used for more than 20 years in the treatment of acid-related diseases such as gastro-duodenal ulcers and reflux esophagitis. Both LPZ and OPZ are derivatives of 2-[(2-
View All Related Papers

Chromatograms

application for HPLC

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