L7647
Concanavalin A from Canavalia ensiformis (Jack bean)
Type VI, lyophilized powder
Synonym(s):
Con A
Sign Into View Organizational & Contract Pricing
All Photos(3)
About This Item
Recommended Products
biological source
Canavalia ensiformis
type
Type VI
form
lyophilized powder
potency
≤20 μg per mL agglutination activity
impurities
Carbohydrate, essentially free
salt, essentially free
solubility
water: 1 % (w/v)
storage temp.
−20°C
Looking for similar products? Visit Product Comparison Guide
Related Categories
Application
Concanavalin A from Canavalia ensiformis (Jack bean) has been used for developing zwitterion-immobilized molecularly imprinted polymers (ziMIPs) for protein crystallization. It has been also used in the preparation of protein loaded microgels to prevent enzymatic degradation of microgels for monitoring by confocal laser scanning microscope (CLSM).
Biochem/physiol Actions
Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Preparation Note
Highly purified by specific affinity chromatography.
Analysis Note
Agglutination activity: Determined from serial dilutions of a 1 mg/mL solution (this activity is the lowest conc. to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C). Requires Type A Human Blood.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Sevan Arabaciyan et al.
Frontiers in cell and developmental biology, 9, 607628-607628 (2021-02-16)
Single-cell variability of growth is a biological phenomenon that has attracted growing interest in recent years. Important progress has been made in the knowledge of the origin of cell-to-cell heterogeneity of growth, especially in microbial cells. To better understand the
Derivatization of epoxy-activated agarose with various carbohydrates for the preparation of stable and high-capacity affinity adsorbents: their use for affinity chromatography of carbohydrate-binding proteins.
I Matsumoto et al.
Analytical biochemistry, 116(1), 103-110 (1981-09-01)
Zwitterion-Immobilized Imprinted Polymers for Promoting the Crystallization of Proteins
Xing Y, et al.
Crystal Growth & Design, 15(10), 4932-4937 (2015)
Marion Schiavone et al.
FEMS yeast research, 15(2) (2015-03-13)
The Saccharomyces cerevisiae cell surface is endowed with some relevant technological properties, notably antimicrobial and biosorption activities. For these purposes, yeasts are usually processed and packaged in an 'autolysed/dried' formula, which may have some impacts on cell surface properties. In
Mauricio Berriel Diaz et al.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 208, 219-242 (2016-12-03)
Multiple epidemiological studies demonstrated that overweight and obesity significantly increase the risk of several types of cancer. As the prevalence of obesity is dramatically rising, it is expected that it will represent one of the major lifestyle-associated risk factors for
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service