L5408
LY-171,883
≥98% (TLC)
Synonym(s):
5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole, Tomelukast
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About This Item
Empirical Formula (Hill Notation):
C16H22N4O3
CAS Number:
Molecular Weight:
318.37
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
SMILES string
CCCc1c(O)c(ccc1OCCCCc2nnn[nH]2)C(C)=O
InChI
1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChI key
MWYHLEQJTQJHSS-UHFFFAOYSA-N
Biochem/physiol Actions
Selective leukotriene D4 (LTD4) receptor antagonist; PPARα and PPARγ agonist.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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G Chen et al.
International archives of allergy and immunology, 116(2), 132-139 (1998-07-04)
Airway hyperreactivity is a hallmark of asthma. Yet, the role of allergic sensitization in the hyperreactivity remains controversial. This study examined the effects of airborne cockroach allergen (CRa) sensitization on the contractility of bronchial (BSM) and tracheal (TSM) smooth muscle
Milan Randić et al.
Journal of proteome research, 4(6), 2133-2136 (2005-12-13)
We report on an observed regularity in the overall response of cell proteome under influence of different doses of a peroxisome proliferator. Our analysis for the first time demonstrates presence of hormesis at the cellular level. It is shown that
K Yamakawa et al.
Biochemical and biophysical research communications, 271(3), 571-574 (2000-05-18)
Vascular endothelial growth factor (VEGF), expressed in a variety of mesenchymal cells including vascular smooth muscle cells (VSMC), is a potent mitogen for endothelial cells, and is used clinically applied for ischemic disease of peripheral vessels. To determine whether peroxisome
A Przylipiak et al.
European journal of obstetrics, gynecology, and reproductive biology, 77(1), 61-65 (1998-04-29)
The aim of this work was to study the action of leukotrienes on the growth of human mammary cancer cells MCF-7. The growth of the cells was measured by incorporation of 3H-thymidine. The action of leukotriene (LT)B4, LTD4, LTC4, LTE4
T Tanaka et al.
Forensic science international, 71(1), 57-64 (1995-01-21)
We studied the effects of a selective antagonist of peptide leukotriene D4/E4 (LY-171883) and 5-lipoxygenase inhibitor diethylcarbamazine (DEC) in renal failure induced by a tourniquet, because peptide leukotrienes (LTs) were suggested to play a key role in our previous study.
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