J4024
JHW 007 hydrochloride
≥98% (HPLC), solid
Synonym(s):
(3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C24H29F2NO · HCl
CAS Number:
Molecular Weight:
421.95
MDL number:
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: ~10 mg/mL
storage temp.
2-8°C
SMILES string
CCCCN1C2CCC1CC(C2)OC(c3ccc(F)cc3)c4ccc(F)cc4
Biochem/physiol Actions
Selective antagonist of the cocaine site on dopamine transporter.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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G E Agoston et al.
Journal of medicinal chemistry, 40(26), 4329-4339 (1998-01-22)
A series of N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues has been prepared that function as dopamine uptake inhibitors. The N-methylated analogue of this series had a significantly higher affinity for the dopamine transporter than the parent compound, N-methyl-3 alpha- (diphenylmethoxy)tropane (benztropine, Cogentin).
Rajeev I Desai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(8), 1889-1893 (2005-02-25)
There is a large unmet medical need for cocaine addiction treatments. Studies have indicated that the dopamine transporter (DAT) is the primary biological target of cocaine, and most drugs that have DAT affinity have behavioral effects like those of cocaine.
Sangeeta Raje et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 801-808 (2003-09-11)
The N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropanes (AHN 2-003, AHN 1-055, AHN 2-005, and JHW 007) bind with high affinity to the dopamine transporter and inhibit dopamine uptake more potently than cocaine, but they demonstrate behavioral profiles in animal models of psychostimulant abuse that
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