I2784
INH2BP
≥98% (HPLC), solid
Synonym(s):
5-Iodo-6-amino-1,2-benzopyrone
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About This Item
Empirical Formula (Hill Notation):
C9H6INO2
CAS Number:
Molecular Weight:
287.05
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
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Assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 31 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Nc1ccc2OC(=O)C=Cc2c1I
InChI
1S/C9H6INO2/c10-9-5-1-4-8(12)13-7(5)3-2-6(9)11/h1-4H,11H2
InChI key
WWRAFPGUBABZSD-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1); anti-apoptotic.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Raquel M Forsythe et al.
Shock (Augusta, Ga.), 17(3), 180-184 (2002-03-20)
Studies indicate that endotoxin (LPS) causes intestinal injury, increases inducible nitric oxide synthase (iNOS) activity, leads to increased NO production, and promotes bacterial translocation (BT). To investigate the mechanism by which LPS causes gut injury and to test the hypothesis
C Szabó et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3867-3872 (1998-05-09)
Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS-/-)
Lina Du et al.
The Journal of biological chemistry, 278(20), 18426-18433 (2003-03-11)
Poly(ADP-ribosylation), primarily via poly(ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA transcription in cells. However, during conditions of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mitochondrial failure and cell death.
G A Cole et al.
Biochemical and biophysical research communications, 180(2), 504-514 (1991-10-31)
The effects of two adenosine diphosphoribose transferase (ADPRT) enzyme inhibitory ligands, 6-amino-1,2-benzopyrone and its 5-iodo-derivative, were determined in AA-2 and MT-2 cell cultures on the replication of HIV-1 IIIb, assayed by an immunochemical test for the HIV protein p24, and
E Kirsten et al.
International journal of molecular medicine, 5(3), 279-281 (2000-02-26)
The cellular pharmacologic actions, as measured by cell killing, of INH2BP, DIME and INO2BA (+ BSO) were determined in three types of cancer cells and compared to their action on quiescent confluent human foreskin fibroblast (HSF) and pre-confluent growing fibroblasts.
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