H9791

Hyp9

• Synonym(s): 1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone, 2,4-(bis-1-ketohexyl)phloroglucinol
• Empirical Formula (Hill Notation): C₁₈H₂₆O₅
• CAS Number: 3118-34-1
• Molecular Weight: 322.40
• MDL number: MFCD16875422
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815271
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to light yellow
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCC)c1O
• InChI: 1S/C18H26O5/c1-3-5-7-9-12(19)16-14(21)11-15(22)17(18(16)23)13(20)10-8-6-4-2/h11,21-23H,3-10H2,1-2H3
• InChI key: JRHOSBCIYWDGHN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable