H6028
4′-Hydroxymethyltrioxsalen
Synonym(s):
4′-Hydroxymethyl-4,5′,8′-trimethylpsoralen
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About This Item
Empirical Formula (Hill Notation):
C15H14O4
CAS Number:
Molecular Weight:
258.27
MDL number:
UNSPSC Code:
12352200
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storage temp.
2-8°C
SMILES string
CC1=CC(=O)Oc2c(C)c3oc(C)c(CO)c3cc12
Biochem/physiol Actions
A photosensitizing agent known to intercalate into double stranded DNA. May be useful for targeted mutagenesis and in cross-linking DNA-binding protein to DNA.
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S S Sastry et al.
Biochemistry, 32(21), 5526-5538 (1993-06-01)
We have developed a technique for cross-linking DNA binding proteins to DNA using psoralen furanside monoadducts as photoaffinity probes and a continuous-wave argon ion laser (366 nm) as a light source. Several DNA binding proteins (T7 RNA polymerase, UvrB, single-stranded
P A Havre et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(16), 7879-7883 (1993-08-15)
Oligonucleotides can bind as third strands of DNA in a sequence-specific manner in the major groove in homopurine/homopyrimidine stretches in duplex DNA. Here we use a 10-base triplex-forming oligonucleotide linked to a psoralen derivative at its 5' end to achieve
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