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About This Item
Empirical Formula (Hill Notation):
C9H12FN3O4
CAS Number:
Molecular Weight:
245.21
MDL number:
UNSPSC Code:
12352204
storage temp.
2-8°C
SMILES string
NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2F
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Helmling et al.
Nucleosides, nucleotides & nucleic acids, 22(5-8), 1035-1038 (2003-10-21)
Synthesis of 2'-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2'-fluoro-Spiegelmers binding to a neuropeptide.
S Schmidt et al.
Biochimica et biophysica acta, 1130(1), 41-46 (1992-02-28)
Protected 2'-deoxy-2'-fluorouridine and 2'-deoxy-2'-fluorocytidine suitable for incorporation into oligonucleotides via the phosphoramidite approach have been prepared. Five modified and two unmodified oligonucleotides have been synthesized to investigate the regiospecific cleavage of a 5S RNA from Escherichia coli by RNase H.
Robert S Jansen et al.
Rapid communications in mass spectrometry : RCM, 23(19), 3040-3050 (2009-08-26)
A novel assay for the simultaneous quantification of the widely used anticancer agent 2',2'-difluorodeoxycytidine (gemcitabine; dFdC), its deaminated metabolite 2',2'-difluorodeoxyuridine (dFdU) and their mono-, di- and triphosphates (dFdCMP, dFdCDP, dFdCTP, dFdUMP, dFdUDP and dFdUTP) in peripheral blood mononuclear cells (PBMCs)
Lieven J Stuyver et al.
Antimicrobial agents and chemotherapy, 48(2), 651-654 (2004-01-27)
2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due
Frank C Richardson et al.
Chemical research in toxicology, 15(7), 922-926 (2002-07-18)
Apatmers are synthesized using 2'-fluoropyrimdines in place of normal pyrmidines to stabilize them against enzymatic degradation, and thereby improve their therapeutic efficacy. Despite this stabilizing effect, the apatmers can still be degraded by nucleases in the blood. Primer template extension
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