Skip to Content
Merck
All Photos(1)

Documents

D2375

Sigma-Aldrich

N,O-Didansyl-L-tyrosine cyclohexylammonium salt

≥95% (TLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C33H33N3O7S2 · C6H13N
CAS Number:
102783-47-1
Molecular Weight:
746.94
MDL number:
MFCD00058031
UNSPSC Code:
12352200
PubChem Substance ID:
329798736

Assay

≥95% (TLC)

form

solid

technique(s)

ligand binding assay: suitable

storage temp.

−20°C

SMILES string

NC1CCCCC1.CN(C)c2cccc3c(cccc23)S(=O)(=O)N[C@@H](Cc4ccc(OS(=O)(=O)c5cccc6c(cccc56)N(C)C)cc4)C(O)=O

InChI

1S/C33H33N3O7S2.C6H13N/c1-35(2)29-13-5-11-26-24(29)9-7-15-31(26)44(39,40)34-28(33(37)38)21-22-17-19-23(20-18-22)43-45(41,42)32-16-8-10-25-27(32)12-6-14-30(25)36(3)4;7-6-4-2-1-3-5-6/h5-20,28,34H,21H2,1-4H3,(H,37,38);6H,1-5,7H2/t28-;/m0./s1

InChI key

MVXVRKZUVTWXRD-JCOPYZAKSA-N

Biochem/physiol Actions

N,O-Didansyl-L-tyrosine (DDT), a potent inhibitor of bacterial thymidylate synthases, is used as a starting lead for development of novel non-substrate-like inhibitors of bacterial thymidylate synthase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Donatella Tondi et al.
Journal of medicinal chemistry, 48(4), 913-916 (2005-02-18)
N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a submicromolar inhibitor of Lactobacillus casei TS (LcTS), which is highly specific with respect to human TS
Sanuele Calò et al.
Chembiochem : a European journal of chemical biology, 9(5), 779-790 (2008-03-18)
The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets for functional studies and drug discovery. Thymidylate synthase (TS, ThyA) governs the synthesis of thymidylate
T A Fritz et al.
Chemistry & biology, 8(10), 981-995 (2001-10-09)
Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inhibitors of an essential enzyme, thymidylate synthase (TS), were developed using a combination of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service