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D003

R(−)-Apocodeine hydrochloride

solid

Synonym(s):

R(−)-10-Methoxy-11-hydroxyaporphine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H19NO2 · HCl
CAS Number:
641-36-1
Molecular Weight:
317.81
UNSPSC Code:
12352200
PubChem Substance ID:
24277894
MDL number:
MFCD00055171
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form

solid

optical activity

[α]22/D −43° in methanol(lit.)

color

off-white

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

Cl[H].[H][C@]12Cc3ccc(OC)c(O)c3-c4cccc(CCN1C)c24

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Biochem/physiol Actions

Dopamine receptor agonist; apomorphine metabolite.

Disclaimer

Photosensitive

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
070K4611
111K4609
050K4610

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Gessa, et al., eds.
Apomorphine and Other Dopaminomimetics, Vols. 1 and 2 (1981)
R van der Geest et al.
Journal of chromatography. B, Biomedical sciences and applications, 702(1-2), 131-141 (1998-02-04)
Analytical methods are described for the selective, rapid and sensitive determination of R- and S-apomorphine, apocodeine and isoapocodeine and the glucuronic acid and sulfate conjugates in plasma and urine. The methods involve liquid-liquid extraction followed by high-performance liquid chromatography with
R V Smith et al.
Journal of natural products, 46(1), 79-91 (1983-01-01)
A solid basis for the M4-approach has been developed over the past 10 years. Recent examples of the production of difficult-to-synthesize mammalian metabolites through microbial transformations attest to the utility of the methodology. There is, however, much more to be
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