Skip to Content
Merck
All Photos(1)

Documents

C8984

Sigma-Aldrich

Z-Leu-Leu-Leu-fluoromethyl ketone

≥90% (TLC)

Synonym(s):

Z-LLL-FMK

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C27H42N3O5F
Molecular Weight:
507.64
MDL number:
MFCD03453603
UNSPSC Code:
12352200
PubChem Substance ID:
329775191
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Assay

≥90% (TLC)

form

powder

solubility

acetone: 10 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)CF

InChI

1S/C27H42FN3O5/c1-17(2)12-21(24(32)15-28)29-25(33)22(13-18(3)4)30-26(34)23(14-19(5)6)31-27(35)36-16-20-10-8-7-9-11-20/h7-11,17-19,21-23H,12-16H2,1-6H3,(H,29,33)(H,30,34)(H,31,35)/t21-,22-,23-/m0/s1

InChI key

HLXJVMRDGBCZCM-VABKMULXSA-N

Amino Acid Sequence

Z-Leu-Leu-Leu-FMK

Biochem/physiol Actions

Z-Leu-Leu-Leu-fluoromethyl ketone is a proteosome inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tianling Ou et al.
PLoS pathogens, 17(1), e1009212-e1009212 (2021-01-20)
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establish its usefulness as treatment for COVID-19. This compound is

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service