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C8890

Sigma-Aldrich

4-Chloro-1-naphthol

horseradish peroxidase substrate, fluorogenic, ≥98% (GC), crystalline

Synonym(s):

4-chloronaphthalen-1-ol

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About This Item

Linear Formula:
ClC10H6OH
CAS Number:
604-44-4
Molecular Weight:
178.61
Beilstein:
509750
EC Number:
210-068-5
MDL number:
MFCD00003974
UNSPSC Code:
12352204
PubChem Substance ID:
57654054
NACRES:
NA.83

product name

4-Chloro-1-naphthol, crystalline

Assay

≥98% (GC)

Quality Level

200

form

crystalline

mp

118-121 °C (lit.)

solubility

acetone: 50 mg/mL, clear, colorless to very faintly brown

storage temp.

−20°C

SMILES string

Oc1ccc(Cl)c2ccccc12

InChI

1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H

InChI key

LVSPDZAGCBEQAV-UHFFFAOYSA-N

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Application

4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.

Biochem/physiol Actions

4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.

Substrates

Chromogenic peroxidase substrate useful in enzyme-linked detection procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Limited proteolysis of fibrinogen by fibrinogenase from Echis multisquamatis venom
Chernyshenko VO
The Protein Journal, 34(2), 130-134 (2015)
Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation
JIMENEZ JJ, et al.
Journal of Thrombosis and Haemostasis, 3(6), 1301-1308 (2005)
R Kobayashi et al.
Analytical biochemistry, 183(1), 9-12 (1989-11-15)
A method which allows the highly sensitive and simple immunodetection of antigen-antibody complexes on nitrocellulose papers has been developed. The method is a modification of the procedure known as the "Nadi reaction" (oxidative coupling of 1-naphthol and N,N'-dimethyl-p-phenylendiamine) for histochemical
A Domingo et al.
Analytical biochemistry, 182(1), 176-181 (1989-10-01)
As described in this article, visualization and/or photography under uv light of 4-chloro-1-naphthol-developed, peroxidase-marked immunoblots allows an increase in sensitivity of more than 100 times over the apparent staining results observable under normal visible white light. This increase in sensitivity
D J Litman et al.
Clinical chemistry, 29(9), 1598-1603 (1983-09-01)
We describe an internally referenced immunochemical test-strip for use in the rapid detection of morphine. The method is based on the "enzyme-channelling" immunoassay technique, and a glucose oxidase-horseradish peroxidase enzyme pair is used to immunospecifically generate an insoluble, colored reaction
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