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C5554

Sigma-Aldrich

1-(3-Chlorophenyl)piperazine hydrochloride

Synonym(s):

m-CPP

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About This Item

Empirical Formula (Hill Notation):
C10H13ClN2 · xHCl
CAS Number:
65369-76-8
Molecular Weight:
196.68 (free base basis)
EC Number:
265-718-0
MDL number:
MFCD00039032
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

mp

210-214 °C (dec.) (lit.)

SMILES string

Cl.Clc1cccc(c1)N2CCNCC2

InChI

1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H

InChI key

MHXPYWFZULXYHT-UHFFFAOYSA-N

Gene Information

human ... HTR2C(3358)

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Biochem/physiol Actions

5-HT2c serotonin receptor agonist; metabolite of trazodone.

replaced by

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S Rotzinger et al.
Drug metabolism and disposition: the biological fate of chemicals, 26(6), 572-575 (1998-06-17)
The metabolism of the antidepressant drug trazodone to its active metabolite, m-chlorophenylpiperazine (mCPP), was studied in vitro using human liver microsomal preparations and cDNA-expressed human cytochrome P450 (P450) enzymes. The kinetics of mCPP formation from trazodone were determined, and three
L Steardo et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 266-273 (2000-09-19)
There are some suggestions that, in the pineal gland, serotonin acts not only as a precursor of melatonin but also plays a role in the modulation of the pineal biosynthetic activity. To corroborate this possible neuromodulatory role of 5-hydroxytryptamine (serotonin)
Y Tozawa et al.
Biochemical pharmacology, 58(8), 1329-1334 (1999-09-16)
Isatin, a stress-related biological substance, increases in rat urine in association with elevated catecholamine biosynthesis during stress. The goal of this study was to unravel how the biosynthetic pathway of isatin is related to stress response. The importance of the

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