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40754

Sigma-Aldrich

Dansylamidoethyl methanethiosulfonate

≥75.0% (coupling rate)

Synonym(s):

2-(5-Dimethylamino1-naphthylsulfonamido)ethyl methanethiosulfonate, MTS-Dansyl

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About This Item

Empirical Formula (Hill Notation):
C15H20N2O4S3
Molecular Weight:
388.53
UNSPSC Code:
12352200
PubChem Substance ID:
329756018

Assay

≥75.0% (coupling rate)

shelf life

limited shelf life, expiry date on the label

fluorescence

λem 510-530 nm

storage temp.

−20°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCSS(C)(=O)=O

InChI

1S/C15H20N2O4S3/c1-17(2)14-8-4-7-13-12(14)6-5-9-15(13)24(20,21)16-10-11-22-23(3,18)19/h4-9,16H,10-11H2,1-3H3

InChI key

ZKELPZYUWUFQLZ-UHFFFAOYSA-N

Application

Dansylamidoethyl methanethiosulfonate (MTS-Dansyl), a dansylation reagent, is used to dansylate proteins via coupling to sulfhydryls present in cysteine side chains. Dansylation of protein cysteine groups facilitates their detection and study in vivo and in vitro.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
1410026

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Soo-Jin Park et al.
Rapid communications in mass spectrometry : RCM, 19(21), 3089-3096 (2005-10-06)
A database search using peptide mass fingerprints obtained by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry leads to protein identification with incomplete sequence coverage, because certain peptides are preferentially desorbed/ionized and some are not detected at all. We show that certain
K Tanizawa et al.
Chemical & pharmaceutical bulletin, 38(9), 2606-2609 (1990-09-01)
Specific labeling of tyrosine residues of Streptomyces subtilisin inhibitor (SSI) was carried out by dansyl chloride. Analysis revealed that two tyrosine residues out of three in SSI were modified. The resulting fluorescent SSI was fully active as a subtilisin inhibitor.
J A Beeley et al.
Electrophoresis, 17(3), 505-506 (1996-03-01)
Detection of human parotid salivary proteins by dansylation and UV-transillumination after sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) has been compared with Coomassie Blue R-250 and silver staining procedures. Dansylation gives superior results in terms of both resolution and sensitivity, especially

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