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08486

Sigma-Aldrich

5-Pyridoxolactone

≥98.5% (HPLC and enzymatic)

Synonym(s):

3-Carboxy-4-(hydroxymethyl)-5-hydroxy-6-methylpyridine lactone, 5-Pyridoxic acid γ-lactone, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one, NSC 15983, NSC 41813

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About This Item

Empirical Formula (Hill Notation):
C8H7NO3
CAS Number:
4543-56-0
Molecular Weight:
165.15
UNSPSC Code:
12352200
NACRES:
NA.79
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Assay

≥98.5% (HPLC and enzymatic)
98.5-101.5% (T)

form

powder

technique(s)

HPLC: suitable

color

white to light yellow

storage temp.

−20°C

InChI

1S/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3

InChI key

PPAXBSPBIWBREI-UHFFFAOYSA-N

General description

5-pyridoxolactone is a metabolite of vitamin B6.[1]

Biochem/physiol Actions

5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
STBF3009V

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Identification of 5-pyridoxic acid and 5-pyridoxic acid lactone as metabolites of vitamin B6 in humans.
Mahuren, J. D., et al.
The Journal of Nutritional Biochemistry, 2, 449-453 (1991)
Jun Peng et al.
Analytica chimica acta, 803, 97-105 (2013-11-13)
A large fraction of the known human metabolome belong to organic acids. However, comprehensive profiling of the organic acid sub-metabolome is a major analytical challenge. In this work, we report an improved method for detecting organic acid metabolites. This method
Determination of 5-pyridoxic acid, 5-pyridoxic acid lactone, and other vitamin B6 compounds by cation-exchange high-performance liquid chromatography.
J D Mahuren et al.
Methods in enzymology, 280, 22-29 (1997-01-01)
Vitamins (2013)
Y J Jong et al.
The Journal of biological chemistry, 261(32), 15112-15114 (1986-11-15)
4-Pyridoxolactone and 5-pyridoxolactone, formed by dehydrogenation of pyridoxal or isopyridoxal during the bacterial degradation of vitamin B6 by Pseudomonas MA-1 and Arthrobacter Cr-7, respectively, are hydrolyzed to the corresponding acids by distinct inducible lactonases which were purified to homogeneity. 4-Pyridoxolactonase
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