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O5380

Supelco

Oxethazaine

analytical standard

Synonym(s):

2-Hydroxyethyliminobis(N-[α,α-dimethylphenethyl]-N-methylacetamide), Oxetacaine

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About This Item

Empirical Formula (Hill Notation):
C28H41N3O3
CAS Number:
126-27-2
Molecular Weight:
467.64
EC Number:
204-780-5
MDL number:
MFCD00079202
UNSPSC Code:
41116107
PubChem Substance ID:
329818914
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2

InChI

1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

InChI key

FTLDJPRFCGDUFH-UHFFFAOYSA-N

General description

Oxethazaine is a topical anesthetic, administered as an antacid for treating pain associated with duodenal ulcer, esophagitis and gastritis.

Application

Oxethazaine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048F0668

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A Zanni et al.
Current medical research and opinion, 10(2), 128-134 (1986-01-01)
A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone. Patients took
R Yasuno et al.
Biological & pharmaceutical bulletin, 21(12), 1294-1299 (1999-01-09)
Oxethazaine (OXZ), a potent topical anesthetic, was found to induce red blood cell (RBC) lysis in vitro, depending upon concentrations of OXZ, RBC and Ca2+. In a 2% RBC suspension, 100 microM OXZ caused almost complete hemolysis in the presence
Yasusuke Masuda
Journal of pharmacological sciences, 100(3), 167-174 (2006-03-07)
The liver has an intricate microvascular system that allows homogenous perfusion throughout the organ. However, the regulatory mechanisms of intrahepatic circulation are still unclear, and the effects of drugs on this system have rarely been reported. Oxethazaine, a topical anesthetic
[Resorption of cyclosporin administered by oral route to renal transplant patients. Influence of breakfast and an antacid drug].
F Penouil et al.
Therapie, 43(1), 15-19 (1988-01-01)
T Takagi et al.
The American journal of physiology, 255(4 Pt 1), G522-G528 (1988-10-01)
Celiac and superior mesenteric arterial blood flows were measured simultaneously in conscious beagle dogs. The responses to food were completely different between the two arteries. Celiac flow increased quickly to 180-200% of the control 2 min after food but started
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