MTOX1302
Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells
canine kidney (cocker spaniel)
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About This Item
UNSPSC Code:
41106514
NACRES:
NA.81
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Product Name
Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells,
biological source
canine kidney (cocker spaniel)
form
liquid
shipped in
dry ice
storage temp.
−196°C
Gene Information
human ... ABCG2(9429)
General description
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP and Human OATP2B1 has been transfected into the MDCKII cell line. Validation studies have shown BCRP dependent efflux of estrone-3 sulfate (requires OATP2B1) and teriflunomide (does not require OATP2B1).
Features and Benefits
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.
Quality
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.
Legal Information
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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