The exact formulation is proprietary, but the Safety Data Sheet (SDS) states that the product contains between 30 to 50% ethanol. HistoChoice Tissue Fixative (H2904) has been discontinued without a replacement. The HistoChoice Clearing Agent (H2997) is not a suitable substitute for product H2904. While there are other fixatives for cells and tissue, none are specifically marketed for antibody probing applications and in situ hybridizations. Ethanol- or glyoxal-based fixatives are possible alternatives. Another potential replacement is Formalin Free Tissue Fixative, available under catalog number A5472 in 1-liter containers.
To inquire about this product H2904, please contact your local Merck office or dealer. Contact Technical Service
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Application
Designed for the molecular biologist. Specially formulated to preserve antigenic sites for antibody probes and nucleic acid sites for in situ hybridizations. Fixed sections do not require predigestion or other recovery procedures to make important sites available.
Quality
Contains no formaldehyde, glutaraldehyde or mercury. Non-toxic
Legal Information
HistoChoice is a registered trademark of Amresco, Inc.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Michael E Titford et al.
Archives of pathology & laboratory medicine, 129(4), 502-506 (2005-03-30)
In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology. To assess histomorphology with different
M A Kacena et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 79(5-6), 185-190 (2005-03-15)
We compared histochemical and immunohistochemical staining as well as fluorochrome labeling in murine bone specimens that were fixed with 10% neutral buffered formalin to those fixed with HistoChoice. We showed that sections from undecalcified tibiae fixed for 4 h in
D G Vince et al.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology, 15(2), 119-129 (1997-01-01)
Formaldehyde fixatives have traditionally been used to preserve tissues as they impart excellent morphological preservation. Formaldehyde fixes tissue by cross linking, a process which can reduce the antigenicity of tissue and weakens the intensity of immunohistochemical stains. Preliminary studies have
Erik P Rader et al.
Aging cell, 17(5), e12816-e12816 (2018-07-12)
Snell dwarf mice (Pit1dw/dw ) exhibit deficiencies in growth hormone, prolactin, and thyroid stimulating hormone. Besides being an experimental model of hypopituitarism, these mice are long-lived (>40% lifespan extension) and utilized as a model of slowed/delayed aging. Whether this longevity
J Melrose et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(1), 47-53 (2008-06-24)
Histochoice is a proprietary nontoxic, non-cross-linking fixative designed by the manufacturer to replace formaldehyde based fixation protocols. We compared Histochoice and formalin fixation for several cartilaginous tissues including, articular and growth plate cartilage, meniscus and intervertebral disc. The tissues were
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