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78480

Sigma-Aldrich

p-Phenylene diisothiocyanate

purum, ≥98.0% (N)

Synonym(s):

1,4-Diisothiocyanatobenzene, Bitoscanate, PDITC

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About This Item

Linear Formula:
C6H4(NCS)2
CAS Number:
4044-65-9
Molecular Weight:
192.26
Beilstein:
2414340
EC Number:
223-741-3
MDL number:
MFCD00004811
UNSPSC Code:
12352200
PubChem Substance ID:
24887312

grade

purum

Assay

≥98.0% (N)

mp

129-131 °C (lit.)
129-131 °C

SMILES string

S=C=Nc1ccc(cc1)N=C=S

InChI

1S/C8H4N2S2/c11-5-9-7-1-2-8(4-3-7)10-6-12/h1-4H

InChI key

OMWQUXGVXQELIX-UHFFFAOYSA-N

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Other Notes

Reagent for solid-phase sequencing

replaced by

Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H315,H319,H334,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Solid-phase Edman degradation. The use of p-phenyl diisothiocyanate to attach lysine- and arginine-containing peptides to insoluble resins.
R A. Laursen et al.
FEBS letters, 21(1), 67-70 (1972-03-01)
T Ogawa et al.
The Japanese journal of surgery, 11(5), 372-376 (1981-01-01)
Inflammatory processes on the hepato-biliary system may play an important role in the pathogenesis of infantile obstructive cholangiopathy (including biliary atresia, neonatal hepatitis and bile duct dilatation). A model of the disease was produced in rats using 1,4-phenylenediisothiocyanate (P.D.T.) P.D.T.
D J Pappin et al.
Analytical biochemistry, 187(1), 10-19 (1990-05-15)
Electroblotted proteins noncovalently bound to polyvinylidene difluoride (PVDF) membranes are typically sequenced using adsorptive sequencer protocols (gas-phase or pulsed-liquid) that do not require a covalent linkage between protein and surface. We have developed simple chemical protocols where proteins are first
S P Liang et al.
Analytical biochemistry, 197(1), 163-167 (1991-08-15)
A new method for immobilization of proteins purified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) prior to sequencing is described. It utilizes a simple apparatus that permits the simultaneous electroelution of proteins from gel slices and attachment to diisothiocyanate-activated glass
M K Walsh et al.
Journal of biochemical and biophysical methods, 47(3), 221-231 (2001-03-14)
The attachment of single-stranded DNA to a solid support has many biotechnology and molecular biology applications. This paper compares different immobilization chemistries to covalently link single-stranded DNA (20 base pairs), oligo(1), onto glass beads via a 5'-amino terminal end. Immobilization
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