23182
(+)-1-(9-Fluorenyl)ethyl chloroformate solution
≥18 mM in acetone, for chiral derivatization, LiChropur™
Synonym(s):
(+)-FLEC solution
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About This Item
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
Molecular Weight:
272.73
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
for chiral derivatization
Quality Level
product line
ChiraSelect™
optical purity
enantiomeric ratio: ≥99.0:1.0 (HPLC)
quality
LiChropur™
concentration
≥18 mM in acetone
technique(s)
HPLC: suitable
refractive index
n20/D 1.359
storage temp.
2-8°C
InChI
1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3
InChI key
SFRVOKMRHPQYGE-UHFFFAOYSA-N
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General description
(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.
Application
(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.
Physical form
solution, 5 mg in 1 mL acetone
Other Notes
Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity
Legal Information
ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
Target Organs
Central nervous system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
1.4 °F
Flash Point(C)
-17 °C
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A Roux et al.
Journal of chromatography, 570(2), 453-461 (1991-10-04)
A method for the determination of the R-(+) and S-(-) enantiomers of propranolol in blood was developed. After extraction with heptane-isopentanol and derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate, excess reagent was removed using solid-phase extraction. The enantiomers were separated on an achiral
N Todoroki et al.
Journal of chromatography. B, Biomedical sciences and applications, 728(1), 41-47 (1999-06-24)
The natural occurrence of N-methyl-D-aspartate (NMDA) is limited to the foot muscle of Scapharca broughtonii; it is a well known compound for its neuroexitatory activity. This paper describes a high-performance liquid chromatographic (HPLC) method for the determination of NMDA in
Zeineb Aturki et al.
Electrophoresis, 25(4-5), 607-614 (2004-02-26)
The indirect resolution of five beta-adrenoreceptor blocking agents (propranolol, oxprenolol, pindolol, metoprolol, and atenolol) using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and capillary electrochromatography (CEC) is reported. Three octadecylsilanized (ODS) silica gel-based stationary phases, differing in particle diameter and carbon
[A method for separation of DL-amino acids].
T H Akiyama et al.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 40(1), 76-83 (1995-01-01)
Sascha Freimüller et al.
Journal of pharmaceutical and biomedical analysis, 30(2), 209-218 (2002-08-23)
An indirect enantioseparation method for robust and precise determination of D-Carnitine (D-C) in L-Carnitine (L-C) in the range of 0.1-1.0% is presented. The method is based on derivatization of Carnitine with (+)-[1-(9-fluorenyl)-ethyl]-chloroformate ((+)-FLEC). The two diastereomers are subsequently separated of
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