This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Immunogen
Recombinant protein corresponding to human Cav1.2 alpha1c.
Application
Anti-Cav1.2 alpha1c, clone 8F9.1 | MABN863 is an antibody against Cav1.2 alpha1c for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected Cav1.2 alpha1c in human cerebellum, human cerebral cortex, and human pancreas tissue.
Research Category Neuroscience
Research Sub Category Developmental Signaling
Quality
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 5.0 µg/mL of this antibody detected Cav1.2 alpha1c in 10 µg of human brain tissue lysate.
Target description
~230 kDa observed. UniProt entry Q13936 describes 37 isoforms produced by alternative splicing.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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