Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

HCYTABG-17K

Millipore

MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Kit

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
Design And Price Your Kit

species reactivity

human

Quality Level

200

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP®)

storage temp.

2-8°C

General description

Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren’s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Magnetic Bead Panel is a 23-plex kit to be used for the simultaneous detection of any or all of the listed analytes in serum and plasma samples.

Application

The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Panel is a bead-based qualitative assay based on the Luminex® xMAP® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.

Analytes available:
Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω

Panel Type: MAGNETIC Immune Response
Cross Reactivity: There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Research Category: Inflammation & ImmunologyResearch Sub-Category: Inflammation & Autoimmune Mechanisms;Inflammation

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H319,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

1–2 of 2 Questions  

  1. Could you please confirm whether the Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit recognizes all IgG subtypes? If so, could you indicate if it recognizes the FC region or H+L?

    1 answer

    1. The Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit measures all IgG isotypes, and its detection is IgG Fc-specific.

      Helpful?

  2. Does the IgG-PE detection conjugate detect all isoforms of IgG?

    1 answer

    1. The mean proportions of IgG subclasses in normal adult serum are as follows: IgG1: 60%, IgG2: 32%, IgG3: 4%, and IgG4: 4%. The conjugate has been tested directly with IgG1, IgG3, and IgG4 and was reactive with all three, indicating a high likelihood of reactivity with IgG2 as well. The antibody (polyclonal) was purified from human IgG Fc from human serum, making it likely to be reactive with all four isotypes.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service