AB9916
Anti-CYP2b10 Antibody
serum, Chemicon®
Synonym(s):
Cytochrome P450 2b10
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Cyp2B10(13088)
General description
CYP2b10 (Cytochrome P450, family 2, subfamily b, polypeptide 10) is a member of the cytochrome P450 superfamily of monooxygenase enzymes which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
Specificity
AB9916 is specific for CYP2b10.
Immunogen
Epitope: AA I182 – T205
Recombinant 2b10
Application
This Anti-CYP2b10 Antibody is validated for use in WB for the detection of CYP2b10.
Quality
Routinely evaluated by immunoblot.
Target description
58kDa
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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Shinhee Park et al.
Acta pharmaceutica Sinica. B, 6(5), 475-491 (2016-10-07)
Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect in intestine. Sixty-day-old
Hemantkumar Chavan et al.
The Journal of biological chemistry, 290(12), 7871-7886 (2015-01-28)
Although endogenous mechanisms that negatively regulate cytochrome P450 (P450) monooxygenases in response to physiological and pathophysiological signals are not well understood, they are thought to result from alterations in the level of endogenous metabolites, involved in maintaining homeostasis. Here we
Cindy Yanfei Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(7), 1038-1049 (2015-11-19)
The xenobiotic-sensing transcription factors (xeno-sensors) AhR, CAR, and PXR upregulate the expression of many drug-processing genes (DPGs) in liver. Previous studies have unveiled profound changes in the basal expression of DPGs during development; however, knowledge on the ontogeny of the
Joseph A Cichocki et al.
The Journal of pharmacology and experimental therapeutics, 361(1), 17-28 (2017-02-06)
Lifestyle factors and chronic pathologic states are important contributors to interindividual variability in susceptibility to xenobiotic-induced toxicity. Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition that can dramatically affect chemical metabolism. We examined the effect of NAFLD on
p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.
Pan Chen et al.
British journal of pharmacology, 174(23), 4345-4361 (2017-09-15)
The tumour suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity. Recent studies have demonstrated that it contributes to metabolic diseases. Here, we investigated the role of p53 in the regulation of bile acid disposition and
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