This support comprises the modified Rink amide linker attached to aminomethylpolystyrene and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.
Applications of Rink Amide AM resin (100-200 mesh)in solid phase organic synthesis include:
In the synthesis of quinazolinone derivatives via intramolecular transamidation.[1]
In the preparation of 2-aminoquinazoline-based compounds using solid-phase peptide synthesis (SPPS) methodology.[2]
For the synthesis of α-aryl ketones via a palladium-catalyzed coupling reaction.[3]
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Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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![FMOC-RINK LINKER p-[(R,S)-α-[1-(9H-Fluoren-9-yl)-methoxyformamido]- 2,4-dimethoxybenzyl]- phenoxyacetic acid Novabiochem®](/deepweb/assets/sigmaaldrich/product/images/840/955/86e012a0-7062-4b63-9cf9-2428a0b9c135/640/86e012a0-7062-4b63-9cf9-2428a0b9c135.jpg)
