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6.18729

Sigma-Aldrich

Trifluoroacetic acid

for chromatography

Synonym(s):

Trifluoroacetic acid solution, TFA

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IN26187290500
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IN26187290500
₹14,000.01

About This Item

Linear Formula:
CF3COOH
CAS Number:
76-05-1
Molecular Weight:
114.02
Beilstein:
5446934
MDL number:
MFCD00004169
UNSPSC Code:
12352106

₹14,000.01

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grade

for chromatography

Quality Level

100

SMILES string

OC(=O)C(F)(F)F

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

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General description

Trifluoroaceticacid (TFA) is used as an additive in HPLC and LC-MS analyses to improve theseparation of basic compounds.[1]

Application

Trifluoroacetic acid can be used as:
  • Ion-pairing reagent in reversed-phase liquid chromatography (RPLC) for peptide separation.[1]
  • An acidic additive in the mobile phase for chiral supercritical fluid chromatography.[2]

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

>212.0 °F - Pensky-Martens closed cup

Flash Point(C)

> 100 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Combined use of isopropylamine and trifluoroacetic acid in methanol-containing mobile phases for chiral supercritical fluid chromatography
De Klerck K, et al.
Journal of Chromatography A, 1234, 72-79 (2012)
Utility of retention prediction model for investigation of peptide separation selectivity in reversed-phase liquid chromatography: impact of concentration of trifluoroacetic acid, column temperature, gradient slope and type of stationary phase
Analytical Chemistry, 82(1), 265-275 (2010)

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