573080
STAT1 Enhancer, 2-NP - CAS 65182-56-1 - Calbiochem
Synonym(s):
2-NP, 2-(1,8-Naphthyridin-2-yl)phenol
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Assay
≥98% (HPLC)
form
solid
color
orange
solubility
DMSO: 10 mg/mL
General description
A cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB. Shown to prolong INF-γ-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.
Biochem/physiol Actions
Selectively enhances cytokine-induced STAT1 transcription activity
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
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Rebecca A Lynch et al.
Cancer research, 67(3), 1254-1261 (2007-02-07)
The transcription factor signal transducer and activator of transcription (STAT) 1 can mediate antiproliferative and proapoptotic effects in cancer cells, and a number of mechanisms have been found whereby STAT1 signaling is attenuated in tumors thereby increasing their malignant behavior.
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