The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
A cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
Biochem/physiol Actions
Cell permeable: yes
ED50 = 2.6 µM for Aβx-40
Primary Target Aβx-40
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
2-Naphthoyl-Val-Phe-CHO
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Green, K.N., et al. 2002. J. Physiol.541.3, 1013. Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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