Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.
Biochem/physiol Actions
Cell permeable: no
Primary Target Induces vasodilation
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Harmful (C)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.
Other Notes
Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11. Moncada, S., et al. 1979. Pharmacol. Rev.30, 293. Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943. Tateson, J.E., et al. 1977. Prostaglandins13, 389.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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International journal of molecular sciences, 22(22) (2021-11-28)
Vascular injury induces the exposure of subendothelial extracellular matrix (ECM) important to serve as substrate for platelets to adhere to the injured vessel wall to avoid massive blood loss. Different ECM proteins are known to initiate platelet adhesion and activation.
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