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850539P

Avanti

Facade™-EPC

3α-hydroxy-7α,12α-di-(((2-(trimethylamino)ethyl)phosphoryl)ethyloxy)-cholane, powder

Synonym(s):

FA-7

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About This Item

Empirical Formula (Hill Notation):
C38H74N2O11P2
CAS Number:
1429405-99-1
Molecular Weight:
796.95
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

mol wt

796.95 g/mol

packaging

pkg of 1 × 25 mg (850539P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850539P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2OCCOP(OCC[N+](C)(C)C)([O-])=O)([H])C[C@H](OCCOP(OCC[N+](C)(C)C)([O-])=O)[C@@]4(C)[C@@]1([H])CC[C@@H]4[C@H](C)CCC

Application

Facade™-EPC has been used to produce bicelles for nuclear magnetic resonance (NMR) experiments. It may be used in crystallization of cytochrome P450 2B subfamily proteins, CYP2B35 and CYP2B37.

Biochem/physiol Actions

Facade™ EPC/FA-7 (3α-hydroxy-7α,12α-di-(((2-(trimethylamino)ethyl)phosphoryl)ethyloxy)-cholane) having phosphocholine groups helps in preparing smaller micelles than the facial amphiphiles (FAs) with nonionic sugar groups.
Facade™ is a mild rim forming surfactants, used in the synthesis of isotropic bicelles which prevents unfolding of soluble globular domains of large membrane proteins.

Packaging

5 mL Amber Glass Screw Cap Vial (850539P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phase Transitions in Small Isotropic Bicelles
Kot EF, et al.
Langmuir, 34(11), 3426-3437 (2018)
Structure-function analysis of mammalian CYP2B enzymes using 7-substituted coumarin derivatives as probes: utility of crystal structures and molecular modeling in understanding xenobiotic metabolism
Shah MB, et al.
Molecular Pharmacology, 89(4), 435-445 (2016)
Faccade detergents as bicelle rim-forming agents for solution NMR spectroscopy
Mineev KS, et al.
Nanotechnology Reviews, 6(1), 93-103 (2017)
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
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