QBD11026
m-dPEG®24-DSPE
>95% (HPLC)
Synonym(s):
m-PEG24-DSPE, DSPE-PEG24-OMe, mPEG-DSPE, mPEG1000-DSPE, mPEG24-DSPE
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About This Item
Empirical Formula (Hill Notation):
C91H180NO33P
Molecular Weight:
1847.36
MDL number:
UNSPSC Code:
12352200
Assay
>95% (HPLC)
form
solid or viscous liquid
reaction suitability
reaction type: Pegylations
polymer architecture
shape: linear
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
Features and Benefits
m-dPEG24-DSPE is the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) modified with a methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG). This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The hydrophilic head is 74 atoms (86.2 Å) long and has a molecular weight of approximately 1100 Daltons. The dPEG24 is a monodisperse equivalent of the polymeric PEG1000.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Gavin T Noble et al.
Trends in biotechnology, 32(1), 32-45 (2013-11-12)
Nanomedicine, particularly liposomal drug delivery, has expanded considerably over the past few decades, and several liposomal drugs are already providing improved clinical outcomes. Liposomes have now progressed beyond simple, inert drug carriers and can be designed to be highly responsive
Jared F Stefanick et al.
ACS nano, 7(4), 2935-2947 (2013-02-21)
PEGylated liposomes are attractive pharmaceutical nanocarriers; however, literature reports of ligand-targeted nanoparticles have not consistently shown successful results. Here, we employed a multifaceted synthetic strategy to prepare peptide-targeted liposomal nanoparticles with high purity, reproducibility, and precisely controlled stoichiometry of functionalities
Jared F Stefanick et al.
ACS nano, 7(9), 8115-8127 (2013-09-06)
Ligand-targeted nanoparticles are emerging drug delivery vehicles for cancer therapy. Here, we demonstrate that the cellular uptake of peptide-targeted liposomes and micelles can be significantly enhanced by increasing the hydrophilicity of the targeting peptide sequence while simultaneously optimizing the EG
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