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D8765

Sigma-Aldrich

Diethylcarbamazine citrate salt

≥98%

Synonym(s):

N,N-Diethyl-4-methyl-1-piperazinecarboxamide citrate salt

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About This Item

Linear Formula:
C10H21N3O · C6H8O7
CAS Number:
1642-54-2
Molecular Weight:
391.42
Beilstein:
3836352
EC Number:
216-696-6
MDL number:
MFCD00039124
UNSPSC Code:
12352100
PubChem Substance ID:
57654136

Assay

≥98%

form

powder

antibiotic activity spectrum

parasites

Mode of action

enzyme | inhibits

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1

InChI

1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

PGNKBEARDDELNB-UHFFFAOYSA-N

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H302,H330

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBV3157
SLBL0026V
SLBF1846V
052K1630
035F0262

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B K Singh et al.
European journal of medicinal chemistry, 43(12), 2717-2723 (2008-03-15)
A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8-21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl esters (2-7) with different alkyl or aralkyl halides in the presence of a combination of anhydrous K(2)CO(3) and catalytic amount of tetrabutyl ammonium bromide.
Koneni V Sashidhara et al.
Bioorganic & medicinal chemistry letters, 22(4), 1527-1532 (2012-01-31)
A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improved in vitro anti-filarial activity and
Debidas Ray et al.
The Indian journal of medical research, 134, 79-82 (2011-08-03)
Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency
Eugene T Richardson et al.
Journal of travel medicine, 19(3), 183-185 (2012-04-26)
We present a case of Loa loa infection in a patient, 21 years after visiting an endemic area for only 4 days. To our knowledge, this case represents the longest time for the diagnosis of loiasis to be made post-exposure
Delynn M Moss et al.
The American journal of tropical medicine and hygiene, 85(2), 229-237 (2011-08-05)
A multiplex bead assay (MBA) was used to analyze serum samples collected longitudinally from children enrolled in a drug trial for treatment of filariasis in Leogane, Haiti. Recombinant antigens Bm14 and Bm33 from Brugia malayi, third polar tube protein (PTP3)
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