79224
1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one
≥96.0% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C13H17N3O
CAS Number:
Molecular Weight:
231.29
Beilstein:
617685
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
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Assay
≥96.0% (HPLC)
mp
188-191 °C
storage temp.
2-8°C
SMILES string
O=C1NCN(c2ccccc2)C13CCNCC3
InChI
1S/C13H17N3O/c17-12-13(6-8-14-9-7-13)16(10-15-12)11-4-2-1-3-5-11/h1-5,14H,6-10H2,(H,15,17)
InChI key
HTQWGIHCFPWKAS-UHFFFAOYSA-N
Gene Information
rat ... Htr1a(24473) , Htr2a(29595) , Htr2c(25187)
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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H Onodera et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 8(4), 568-574 (1988-08-01)
Opioid ([3H]naloxone) and spirodecanone ([3H]spiperone) binding sites in the hippocampus were visualized in the Mongolian gerbil and in the rat using in vitro autoradiography. In the hippocampus, marked differences were noted in the stratum (sr.) pyramidale of the CA1 subfield
P M Laduron
Biochemical pharmacology, 37(1), 37-40 (1988-01-01)
In binding studies, stereospecificity is not a property restricted to receptor sites; indeed stereospecific binding has also been observed for acceptor sites. Therefore it does not represent a decisive criterion to make a binding site, a receptor site. However, in
A Bruinink et al.
Journal of neurochemistry, 40(5), 1227-1236 (1983-05-01)
The ontogeny of binding sites for [3H] spiperone was studied in time-pregnant rats. Binding of [3H]spiperone to fresh homogenates of pre- and postnatal rat forebrain was characterized by Scatchard analysis and competition experiments with a number of dopaminergic and serotonergic
Differentiation of solubilized dopamine receptors from spirodecanone binding sites in rat striatum.
H Gorissen et al.
FEBS letters, 121(1), 133-138 (1980-11-17)
T Araki et al.
Neuroreport, 5(1), 37-40 (1993-10-25)
Using quantitative receptor autoradiography, spirodecanone binding was evaluated in the gerbil hippocampus 1 h-1 month after cerebral ischaemia of 10 min. The spirodecanone binding was unaffected in the hippocampus up to 48 h after ischaemia. Thereafter, increased binding was found
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