533246
2-Fluoro-3-methylpyridine
97%
Synonym(s):
2-Fluoro-3-picoline
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About This Item
Empirical Formula (Hill Notation):
C6H6FN
CAS Number:
Molecular Weight:
111.12
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
97%
refractive index
n20/D 1.476 (lit.)
bp
154-155 °C (lit.)
density
1.098 g/mL at 25 °C (lit.)
SMILES string
Cc1cccnc1F
InChI
1S/C6H6FN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
InChI key
PHGXUFPYCAWEHK-UHFFFAOYSA-N
General description
2-Fluoro-3-methylpyridine, also known as 2-fluoro-3-picoline, can be prepared by reacting 2-amino-3-methylpyridine and 40% fluoroboric acid.2 The signs of the long range coupling constants of 2-fluoro-3-methylpyridine have been obtained by double and triple resonance techniques.
Application
2-Fluoro-3-methylpyridine may be used in the preparation of:
- 2-phenyl-3-methylpyridine
- 2-(4-chlorophenyl)-3-methylpyridine
- 2-(4-fluorophenyl)-3-methylpyridine
- 2-fluoronicotinic acid
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
118.9 °F - closed cup
Flash Point(C)
48.3 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Signs of proton-proton and proton-fluorine spin-spin coupling constants in 2-fluoro-3-methylpyridine. Sigma and pi contributions to coupling in a nitrogen heterocycle.
Schaefer T, et al.
Canadian Journal of Chemistry, 47(9), 1507-1514 (1969)
Proton Magnetic Resonance of the Methyl Derivatives of 2-Fluoropyridine. Sigma and Pi Electron Contributions to Spin-Spin Coupling Constants.
Rowbotham JB, et al.
Canadian Journal of Chemistry, 49(11), 1799-1803 (1971)
Synthesis of 2-and 6-fluoronicotinamides.
Minor JT, et al.
Journal of the American Chemical Society, 71(3), 1125-1126 (1949)
A facile synthesis of 7-halo-5H-indeno [1, 2-b] pyridines and-pyridin-5-ones.
DuPriest MT, et al.
The Journal of Organic Chemistry, 51(11), 2021-2023 (1986)
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