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393576

Sigma-Aldrich

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine

98%

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About This Item

Empirical Formula (Hill Notation):
C6H2ClF4N
CAS Number:
Molecular Weight:
199.53
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.433 (lit.)

bp

50-55 °C/11 mmHg (lit.)

mp

16-20 °C (lit.)

density

1.524 g/mL at 25 °C (lit.)

SMILES string

Fc1ncc(cc1Cl)C(F)(F)F

InChI

1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H

InChI key

GDSROTVTTLUHCO-UHFFFAOYSA-N

General description

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Regioselective substitution in aromatic six-membered nitrogen heterocycles.
Comins DL and O'Connor S.
Advances in Heterocyclic Chemistry, 44, 199-267 (1988)
Catalytic fluorination of 2-chloropyridine over metal oxide catalysts in gas phase in the presence of HF.
Cochon C, et al.
Applied Catalysis A: General, 413, 149-156 (2012)

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