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288144

Sigma-Aldrich

Tricarbonyldichlororuthenium(II) dimer

Synonym(s):

CORM-2

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About This Item

Linear Formula:
[Ru(CO)3Cl2]2
CAS Number:
22594-69-0
Molecular Weight:
512.01
MDL number:
MFCD00011528
UNSPSC Code:
12161600
PubChem Substance ID:
24857320
NACRES:
NA.22

reaction suitability

core: ruthenium
reagent type: catalyst

SMILES string

[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl

InChI

1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4

InChI key

JYHHJVKGDCZCCL-UHFFFAOYSA-J

Related Categories

Application

Carbon monoxide-releasing molecule used for pharamological studies including:
  • Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
  • Investigations of P2X4 as a possible target
  • Possible modification of thrombus growth or disintegration
  • Enhances fibrinogen as a substrate for thrombin
  • Regulation of ion transport by gasotransmitters

Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Cyclopenta [l] phenanthrenyl and Cyclopenta [a] acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols.
Mavrynsky D, et al.
Organometallics, 28(2), 598-605 (2008)
One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes.
Alexakis E, et al.
Tetrahedron Letters, 46(25), 4291-4293 (2005)
Vance G Nielsen et al.
International journal of molecular sciences, 21(6) (2020-03-22)
Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species' neurotoxic venoms that are anticoagulant in nature. The neurotoxic venoms of the four extant species of Dendroaspis (the Black and green mambas)
Po-Min Yang et al.
Vascular pharmacology, 87, 209-218 (2016-10-11)
The production of nitric oxide (NO) by endothelial NO synthase (eNOS) plays a major role in maintaining vascular homeostasis. This study elucidated the potential role of carbon monoxide (CO)-releasing molecules (CORMs) in NO production and explored the underlying mechanisms in
Yu Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 36(6), 791-795 (2016-12-08)
Carbon monoxide (CO), as a vital small molecule in signaling pathways, is found to be involved in ischemia-reperfusion injury (IRI) in renal transplantation. CO-releasing molecule-2 (CORM-2), a CO-releasing molecule, is a type of metal carbonyl complexes which can quickly release
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