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SML3624

Sigma-Aldrich

Cefditoren pivoxil

≥98% (HPLC)

Synonym(s):

(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester, CCRIS 7768, ME 1207

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About This Item

Empirical Formula (Hill Notation):
C25H28N6O7S3
CAS Number:
117467-28-4
Molecular Weight:
620.72
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.25
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[s]1c(nc(c1)\C(=N\OC)\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)OCOC(=O)C(C)(C)C)\C=C/c4[s]cnc4C)N

InChI

1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1

InChI key

AFZFFLVORLEPPO-UVYJNCLZSA-N

Biochem/physiol Actions

Cefditoren pivoxil is a prodrug of an orally available, broad spectrum third-generation cephalosporin antibiotic Cefditoren. It is active against both gram-negative and gram-positive bacteria. Cefditoren pivoxil is used for treatment of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.
Prodrug of an orally available, broad spectrum third-generation cephalosporin antibiotic Cefditoren.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000235180
0000235179
0000229255
0000229255
0000235180

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Taiga Miyazaki et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 25(9), 702-707 (2019-04-16)
Oral antibiotic therapy for patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves an aminopenicillin with clavulanic acid, a macrolide, or a quinolone. To date, however, the clinical efficacy and safety of the oral cephalosporin cefditoren pivoxil
Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae
BMC Microbiology, 21(1), 148-148 (2021)
A Tamura et al.
Antimicrobial agents and chemotherapy, 32(9), 1421-1426 (1988-09-01)
ME1207 (pivaloyloxymethyl ester of ME1206) is a new oral cephalosporin. ME1206 is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)- acetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)-ethyl]-cephem-4-carboxy lic acid. The susceptibilities of about 1,600 clinical isolates to ME1206 were determined by the agar dilution method. ME1206 showed a broad spectrum of activity against

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