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SML3385

Binimetinib

≥98% (HPLC)

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Synonym(s):

5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ARRY 162, ARRY 438162, ARRY-162, ARRY-438162, ARRY162, ARRY438162, MEK 162, MEK-162, MEK162

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Size/SKUAvailabilityPrice
10 mg
Please contact Customer Service for Availability
₪182.00
50 mg
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₪833.00

About This Item

Empirical Formula (Hill Notation):
C17H15BrF2N4O3
CAS Number:
Molecular Weight:
441.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

₪182.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C(C(F)=C(C2=C1)N=CN2C)NC3=C(C=C(C=C3)Br)F)NOCCO

InChI

1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key

ACWZRVQXLIRSDF-UHFFFAOYSA-N

Biochem/physiol Actions

Binimetinib (MEK162, ARRY-162) is an orally active, potent, ATP-uncompetitive MEK1/2 inhibitor (IC50 = 12 nM) that inhibits multiple human tumor growth in xenograft mice in vivo regardless of Kras or Braf mutation (30 or 100 mg/kg/day, 100 mg/kg b.i.d.).
Orally active, potent, ATP-uncompetitive MEK1/2 inhibitor that inhibits multiple human tumor growth in vivo regardless of Kras or Braf mutation.

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This Item
SML0766SAB5700337HPA049318
description

≥98% (HPLC)

description

≥98% (HPLC)

description

-

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

buffered aqueous solution

form

buffered aqueous glycerol solution

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

, white to beige to brown

color

-

color

-


Pictograms

Environment

Hazard Codes

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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