SML3236

UNC10201652

≥98 mg/mL (HPLC)

• Synonym(s): 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, 1,2,3,4-Tetrahydro-5-(4-morpholinyl)-8-(1-piperazinyl)[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinoline
• Empirical Formula (Hill Notation): C₂₀H₂₅N₇OS
• CAS Number: 372495-52-8
• Molecular Weight: 411.52
• UNSPSC Code: 12352107
• NACRES: NA.77
• Form: powder

Properties

• form: powder
• Quality Segment: 100
• concentration: ≥98 mg/mL (HPLC)
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C12=C(N3CCOCC3)N=C(SC4=C5N=NN=C4N6CCNCC6)C5=C1CCCC2
• InChI key: ZPVQONCMKZBGTB-UHFFFAOYSA-N

Description

General description

UNC10201652 is a potent and substrate-dependent slow-binding inhibitor of bacterial β-glucuronidases (GUSs) in the gut. UNC10201652 appears to target a catalytic intermediate. It alleviates irinotecan-induced gut damage in mouse models of cancer.

Biochem/physiol Actions

potent and selective slow binding inhibitor microbiome β-glucuronidase enzyme

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable