SML2811

Phenanthriplatin

>97% (NMR)

• Synonym(s): (SP-4-3)-Diamminechlorido(phenanthridine)platinum(II) nitrate, PhenPt, cis-[Pt(NH3)2(phenanthridine)Cl]NO3
• Empirical Formula (Hill Notation): C₁₃H₁₅ClN₄O₃Pt
• CAS Number: 1416900-51-0
• Molecular Weight: 505.81
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: >97% (NMR)
• Form: powder

Properties

• Quality Segment: 100
• assay: >97% (NMR)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl[Pt](N)([N+]1=C2C=CC=CC2=C3C=CC=CC3=C1)N.[O-][N+]([O-])=O
• InChI key: BELJCNWNXQVJPZ-UHFFFAOYSA-M

Description

Biochem/physiol Actions

Cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity than cisplatin, oxaliplatin, and pyriplatin.

Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC₅₀ in μM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5′-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3