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SML1900

Sobetirome

≥98% (HPLC), thyroid hormone receptor (TR) β and TRα agonist, powder

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Synonym(s):

2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid, 3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylbenzyl)phenoxyacetic acid, GC 1, GC-1

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Size/SKUAvailabilityPrice
5 mg
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₪552.00
25 mg
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₪2,228.00

About This Item

Empirical Formula (Hill Notation):
C20H24O4
CAS Number:
Molecular Weight:
328.40
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

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Product Name

Sobetirome, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O(CC(=O)O)c1cc(c(c(c1)C)Cc2cc(c(cc2)O)C(C)C)C

InChI

1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)

InChI key

QNAZTOHXCZPOSA-UHFFFAOYSA-N

Biochem/physiol Actions

Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action.
Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action. Sobetirome is devoid of thyrotoxic adverse effects on the heart, bone, and skeletal muscle.
Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.

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This Item
SML2798SML3338SML2361
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

>97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>97% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to brown


Storage Class

11 - Combustible Solids

WGK

WGK 3



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