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SML1192

SB290157 trifluoroacetate salt

≥97% (HPLC)

Synonym(s):

N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt, SB 290157 trifluoroacetate salt

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
₪554.00
25 mg
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₪2,059.00

About This Item

Empirical Formula (Hill Notation):
C22H28N4O4 · CF3CO2H
CAS Number:
Molecular Weight:
526.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated

₪554.00


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Quality Segment

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D +1.5 to +5°, c = 1.0 in DMSO

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F

InChI

1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1

InChI key

ZJRMPPVJAQWGEG-FYZYNONXSA-N

Biochem/physiol Actions

SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling.
SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor.

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This Item
559410204884204881
description

≥97% (HPLC)

description

A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM).

description

Complement C3a des-Arg, Human, is a single chain native des-Arg C3 complement component

description

Complement C3a, Human, is a native, single chain C3a complement component. It has many biological activities, such as smooth muscle contraction, platelet activation, & immunoregulatory reactions.

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

powder

form

lyophilized

form

liquid

form

liquid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−70°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL

solubility

-

solubility

-

storage condition

desiccated

storage condition

protect from light, OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles, OK to freeze


Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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