SML0795

PF-670462

≥98% (HPLC)

• Synonym(s): 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride, PF670462
• Empirical Formula (Hill Notation): C₁₉H₂₀FN₅ · 2HCl
• CAS Number: 950912-80-8
• Molecular Weight: 410.32
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)c2nc[n](c2c4nc(ncc4)N)C3CCCCC3.Cl.Cl
• InChI: 1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
• InChI key: PSNKGVAXBSAHCH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC₅₀ values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC₅₀ 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity).

PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I.

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable