While this product is stored frozen at -20°C, it is stable for relatively short periods at room temperature. The item is shipped ambient, and shipping routes are configured to minimize transit time. Freezer storage products that ship at ambient temperature are considered stable up to 2 weeks to allow for transit time.
S8442
SU 5416
≥98% (HPLC), powder, neuronal nitric oxide synthase inhibitor
Synonym(s):
1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | ₪828.00 |
25 mg | Please contact Customer Service for Availability | ₪2,862.00 |
About This Item
Empirical Formula (Hill Notation):
C15H14N2O
CAS Number:
Molecular Weight:
238.28
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
SU 5416, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to yellow-orange
mp
221-222 °C
solubility
DMSO: 20 mg/mL, clear (warmed), H2O: insoluble
storage temp.
−20°C
SMILES string
Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
InChI
1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
InChI key
WUWDLXZGHZSWQZ-XYOKQWHBSA-N
Gene Information
human ... EGFR(1956), FLT1(2321), IGFBP1(3484), IL2(3558), KDR(3791), PDGFRB(5159)
mouse ... Flt1(14254), Kdr(16542)
General description
SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis. SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection.
Application
Biochem/physiol Actions
SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2
SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description targeting mouse Kdr | description - | description Prestige Antibodies® Powered by Atlas Antibodies, clone CL0345, purified immunoglobulin, buffered aqueous glycerol solution |
| form powder | form lyophilized powder | form - | form buffered aqueous glycerol solution |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: insoluble, DMSO: 20 mg/mL, clear (warmed) | solubility - | solubility - | solubility - |
| color yellow to yellow-orange | color - | color - | color - |
Storage Class
11 - Combustible Solids
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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